“Reducing pain and restoring health”
“Reducing pain and restoring health”
Experience, Comprehensive, Compassionate Care with Competitive pricing.
*IV Neridronate equivalent medications with *IV Ketamine *FDA Approved Infrared Laser Light Therapy and *Oral Neridronate Equivalent medications in select cases
Complex regional pain syndrome (CRPS) is a chronic (lasting greater than six months) pain condition that most often affects one limb (arm, leg, hand, or foot) usually after an injury. CRPS is believed to be caused by damage to, or malfunction of, the peripheral and central nervous systems. The central nervous system is composed of the brain and spinal cord; the peripheral nervous system involves nerve signaling from the brain and spinal cord to the rest of the body. CRPS is characterized by prolonged or excessive pain and changes in skin color, temperature, and/or swelling in the affected area. CRPS is divided into two types: CRPS-I and CRPS-II:
Kentuckiana Integrative Medicine offers stand-alone programs that include lifestyle changes to ensure that you get fast, safe and sustainable results. The initial phase of our weight-loss programs include a combination of medications, supplements and meal plans customized to fit your needs and goals.
The following is a list of primary treatments we utilize to achieve fast amazing results:
Other common features of CRPS include:
In Italy over 500 patients. In the first multi-center trial involving 86 patients over 70% reported a 50 % reduction in pain, improved function in activities of daily living and 100% where able to discontinue narcotic pain medication. The available data shows that, if treated within 1 year from the onset of CRPS symptoms, in 32% of cases, the patient can hope for a complete and permanent remission of the disease. However, of the long-term patients, 40% experienced a decrease of pain level by 30 – 40 %, 25 % said their pain decreased by 20%. Only the remaining 2% experienced no effect or benefit. “The Italian team freely admits that those who’ve had CRPS for longer may not experience the same results but they claim that the treatment is “still effective” even for those who’ve had CRPS for years. There are no published papers on trials involving neridronate with patients who have longstanding CRPS, but there are papers on other bisphosphonates that suggest that the treatment might benefit them. It’s just likely that the effect will not be as pronounced as the “cure” patients with younger CRPS might experience.”
It is a clinical diagnosis meaning no blood test or x-ray can prove the presence of CRPS although bone scans, nerve studies may help. According to the Budapest criteria the following must be present to be diagnosed with CRPS / RSD? At least 1 sign at time of evaluation in at least 2 of the following categories:
[In a Triphasic Bone Scan] Typically, a pattern of increased uptake, in all three phases, is found during the first 6 months of the disease in the joints of the affected limb. This pattern is particularly evident during the delayed phase. Finally, MRI may demonstrate bone marrow edema [swelling] of the affected limb, and may be helpful for excluding other diagnoses.2 ,3 ,8 Nevertheless, none of the aforementioned techniques is currently considered a requirement for the diagnosis of CRPS-I.
The outcome of CRPS is highly variable. Younger persons, children, and teenagers tend to have better outcomes. While older people can have good outcomes, there are some individuals who experience severe pain and disability despite treatment. Anecdotal evidence suggests early treatment, particularly rehabilitation, is helpful in limiting the disorder, a concept that has not yet been proven in clinical studies. More research is needed to understand the causes of CRPS, how it progresses, and the role of early treatment.
Some minor side effects (possible low fever and arthralgia immediately after the infusion affect approximately 30% of patients). The smaller the patient, typically, the stronger the reaction. However, it is not a persistent pain and typically only occurs after the first infusion. Common side effects may include:
If the patient suffers from arthritis, severe low back pain, rheumatism, Neridronate equivalent medications may cause some pain, but often help provide relief of arthritis pain, severe low back pain, rheumatisms as well so, in the end, it may be even more beneficial to the patient.
Risks, Problems or complications occur in less than 2% of patients. Most complications occur with long term use of bisphosphonates over years. CRPS treatment typically only involves 4 IV treatments [every 2-3 days] so complications are much less than 1%. In fact, the incidence of renal complications is less than 1% after IV infusion treatments. All Bisphosphonate including Neridronate when used long term may cause kidney injury, electrolyte disturbance and osteonecrosis of the jaw, femur fracture and hypocalcemia [low calcium]. Because of the potential of jaw problems, patients must avoid dental tooth extraction or implants for at least 6-12 months after stopping use of bisphosphonates or other Neridronate equivalent medication.
The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. The NINDS is part of the National Institutes of Health (NIH), the leading supporter of biomedical research in the world. NINDS-supported scientists are studying new approaches to treat CRPS and to intervene more aggressively to limit the symptoms and disability associated with the syndrome.
Other NIH institutes also support research on CRPS and other painful conditions. Previous research has shown that CRPS-related inflammation is caused by the body’s own immune response. Researchers hope to better understand how CRPS develops by studying immune system activation and peripheral nerve signaling using an animal model of the disorder. The animal model was developed to mimic certain CRPS-like features following fracture or limb surgery, by activating certain molecules involved in the immune system process. Limb trauma, such as a fracture, followed by immobilization in a cast, is the most common cause of CRPS.
By studying an animal model, researchers hope to better understand the neuroinflammatory basis of CRPS in order to identify the relevant inflammatory signaling pathways that lead to the development of post-traumatic CRPS. They also will examine inflammatory effects of cast immobilization and exercise on the development of pain behaviors and CRPS symptoms. Peripheral nerve injury and subsequent regeneration often lead to a variety of sensory changes. Researchers hope to identify specific cellular and molecular changes in sensory neurons following peripheral nerve injury to better understand the processes that underlie neuroplasticity (the brain’s ability to reorganize or form new nerve connections and pathways following injury or death of nerve cells). Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following regeneration. Children and adolescents with CRPS generally have a better prognosis than adults, which may provide insights into mechanisms that can prevent chronic pain.
Scientists are studying children with CRPS given that their brains are more adaptable through a mechanism known as neuroplasticity. Scientists hope to use these discoveries in order to develop more effective therapies for CRPS. NINDS-funded scientists continue to investigate how inflammation and the release of adenosine triphosphate (ATP) may induce abnormal connections and signaling between sympathetic and sensory nerve cells in chronic pain conditions such as CRPS. (ATP is a molecule involved with energy production within cells that can also act as a neurotransmitter. Neurotransmitters are chemicals used by nervous system cells to communicate with one another.) A better understanding of changes in nerve connections following peripheral nerve injury may offer greater insight to pain and lead to new treatments.
1-4 hours depending on what other therapies you receive. Driver or Uber required if you receive Ketamine.
If you would like to learn more about our treatments at Kentuckiana Integrative Medicine, call us today at (812) 913-4416 to schedule a consultation. We are located in Jeffersonville, directly across Louisville, KY.